Identifiying Human MHC Supertypes Using Bioinformatic Methods
نویسندگان
چکیده
منابع مشابه
Identifiying human MHC supertypes using bioinformatic methods.
Classification of MHC molecules into supertypes in terms of peptide-binding specificities is an important issue, with direct implications for the development of epitope-based vaccines with wide population coverage. In view of extremely high MHC polymorphism (948 class I and 633 class II HLA alleles) the experimental solution of this task is presently impossible. In this study, we describe a bio...
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Identification of peptides that can bind to major histocompatibility complex (MHC) molecules is important for anticipation of T-cell epitopes and for the design of epitope-based vaccines. Population coverage of epitope vaccines is, however, compromised by the extreme polymorphism of MHC molecules, which is in fact the basis for their differential peptide binding. Therefore, grouping of MHC mole...
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Using an in vitro peptide stimulation strategy, two chimpanzees that were acutely infected by the hepatitis B virus (HBV) produced peripheral blood CTL responses to several HBV-encoded epitopes that are known to be recognized by class I-restricted CTL in acutely infected humans. One animal responded to three HBV peptides that, in humans, are restricted by HLA-A2; the other animal responded to t...
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Major Histocompatibility Complex (MHC) peptide interactions are at the heart of the cellular immune response, as they are responsible for the presentation of pathogen-derived peptides on the surface of infected cells. Therefore considerable experimental and computational efforts have been made to characterize this interaction and predict epitopes for peptide-based vaccines. This task is complic...
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A challenging problem in open information extraction and text mining is the learning of the selectional restrictions of semantic relations. We propose a minimally supervised bootstrapping algorithm that uses a single seed and a recursive lexico-syntactic pattern to learn the arguments and the supertypes of a diverse set of semantic relations from the Web. We evaluate the performance of our algo...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2004
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.172.7.4314